Publications

A curated collection of the publications of the CREANT research team. Happy reading!

2023

Site-specific ⁶⁸Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models.

Dewulf J, Flieswasser T, Delahaye T, Vangestel C, Miranda A, de Haard H, Jacobs J, Smits E, Van den Wyngaert T, Elvas F.. EJNMMI Radiopharm Chem. 2023 Apr 24;8(1):8. doi: 10.1186/s41181-023-00194-3. PMID: 37093350; PMCID: PMC10126183. [Free full text]

2022

Site-specific ⁶⁸Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models.

Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab Fragments.
Dewulf J, Hrynchak I, Geudens S, Pintelon I, Vangestel C, Sereno J, van Dam PA, Abrunhosa AJ, Elvas F, Van den Wyngaert T. Pharmaceutics. 2022 Apr 26;14(5):939. doi: 10.3390/pharmaceutics14050939. PMID: 35631525 Free PMC article.

Radionuclide Imaging of Cytotoxic Immune Cell Responses to Anti-Cancer Immunotherapy.
Lauwerys L, Smits E, Van den Wyngaert T, Elvas F. Biomedicines. 2022 May 5;10(5):1074. doi: 10.3390/biomedicines10051074. PMID: 35625811 Free PMC article. Review.

Positron emission tomography-magnetic resonance imaging as a research tool in musculoskeletal conditions.
Van den Wyngaert T, de Schepper S, Elvas F, Seyedinia SS, Beheshti M. Q J Nucl Med Mol Imaging. 2022 Mar;66(1):15-30. doi: 10.23736/S1824-4785.22.03434-3. Epub 2022 Jan 10. PMID: 35005878 Free article.

2021

Immuno-PET Molecular Imaging of RANKL in Cancer.
Dewulf J, Vangestel C, Verhoeven Y, De Waele J, Zwaenepoel K, van Dam PA, Elvas F, Van den Wyngaert T. Cancers (Basel). 2021 Apr 30;13(9):2166. doi: 10.3390/cancers13092166. PMID: 33946410 Free PMC article.

Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers.
Beroske L, Van den Wyngaert T, Stroobants S, Van der Veken P, Elvas F. Int J Mol Sci. 2021 Apr 11;22(8):3948. doi: 10.3390/ijms22083948. PMID: 33920463 Free PMC article. Review.

2020

Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA^5m chelators.
Moon ES, Elvas F, Vliegen G, De Lombaerde S, Vangestel C, De Bruycker S, Bracke A, Eppard E, Greifenstein L, Klasen B, Kramer V, Staelens S, De Meester I, Van der Veken P, Rösch F. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19. doi: 10.1186/s41181-020-00102-z. PMID: 32728930 Free PMC article.

Development of Antibody Immuno-PET/SPECT Radiopharmaceuticals for Imaging of Oncological Disorders-An Update.
Dewulf J, Adhikari K, Vangestel C, Wyngaert TVD, Elvas F. Cancers (Basel). 2020 Jul 11;12(7):1868. doi: 10.3390/cancers12071868. PMID: 32664521 Free PMC article. Review.

SPECT/CT: Standing on the Shoulders of Giants, It Is Time to Reach for the Sky!
Van den Wyngaert T, Elvas F, De Schepper S, Kennedy JA, Israel O. J Nucl Med. 2020 Sep;61(9):1284-1291. doi: 10.2967/jnumed.119.236943. Epub 2020 Jul 3. PMID: 32620702 Free article. Review.

Preclinical Evaluation of a Novel ¹⁸F-Labeled dTCO-Amide Derivative for Bioorthogonal Pretargeted Positron Emission Tomography Imaging.
Ruivo E, Elvas F, Adhikari K, Vangestel C, Van Haesendonck G, Lemière F, Staelens S, Stroobants S, Van der Veken P, Wyffels L, Augustyns K. ACS Omega. 2020 Feb 26;5(9):4449-4456. doi: 10.1021/acsomega.9b03584. eCollection 2020 Mar 10. PMID: 32175492 Free PMC article.

2019

Improved stability of a novel fluorine-18 labeled TCO analogue for pretargeted PET imaging.
Ruivo E, Adhikari K, Elvas F, Fissers J, Vangestel C, Staelens S, Stroobants S, Van der Veken P, Wyffels L, Augustyns K. Nucl Med Biol. 2019 Sep-Oct;76-77:36-42. doi: 10.1016/j.nucmedbio.2019.11.001. Epub 2019 Nov 5. PMID: 31707309 Free article.

Bone metastases in the era of targeted treatments: insights from molecular biology.
Dewulf J, Vangestel C, Verhoeven Y, van Dam P, Elvas F, Van den Wyngaert T, Clézardin P. Q J Nucl Med Mol Imaging. 2019 Jun;63(2):98-111. doi: 10.23736/S1824-4785.19.03203-5. Epub 2019 Jul 11. PMID: 31298015 Free article. Review.

Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy.
Elvas F, Vanden Berghe T, Adriaenssens Y, Vandenabeele P, Augustyns K, Staelens S, Stroobants S, Van der Veken P, Wyffels L. Org Biomol Chem. 2019 May 15;17(19):4801-4824. doi: 10.1039/c9ob00657e. PMID: 31033991

2018

[^99mTc]duramycin for cell death imaging: Impact of kit formulation, purification and species difference.
Palmieri L, Elvas F, Vangestel C, Pak K, Gray B, Stroobants S, Staelens S, Wyffels L. Nucl Med Biol. 2018 Jan;56:1-9. doi: 10.1016/j.nucmedbio.2017.08.005. Epub 2017 Sep 14. PMID: 29031229

2017

Treatment with A_2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage.
Boia R, Elvas F, Madeira MH, Aires ID, Rodrigues-Neves AC, Tralhão P, Szabó EC, Baqi Y, Müller CE, Tomé ÂR, Cunha RA, Ambrósio AF, Santiago AR. Cell Death Dis. 2017 Oct 5;8(10):e3065. doi: 10.1038/cddis.2017.451. PMID: 28981089 Free PMC article.

Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited.
Adriaenssens Y, Jiménez Fernández D, Vande Walle L, Elvas F, Joossens J, Lambeir A, Augustyns K, Lamkanfi M, Van der Veken P. Org Biomol Chem. 2017 Sep 13;15(35):7456-7473. doi: 10.1039/c7ob01403a. PMID: 28837200

Phosphatidylethanolamine targeting for cell death imaging in early treatment response evaluation and disease diagnosis.
Elvas F, Stroobants S, Wyffels L. Apoptosis. 2017 Aug;22(8):971-987. doi: 10.1007/s10495-017-1384-0. PMID: 28623512 Review.

Evaluation of [¹⁸F]CP18 as a Substrate-Based Apoptosis Imaging Agent for the Assessment of Early Treatment Response in Oncology.
Rapic S, Vangestel C, Elvas F, Verhaeghe J, Van den Wyngaert T, Wyffels L, Pauwels P, Staelens S, Stroobants S. Mol Imaging Biol. 2017 Aug;19(4):560-569. doi: 10.1007/s11307-016-1037-7. PMID: 28050749

2016

^99mTc-Duramycin SPECT Imaging of Early Tumor Response to Targeted Therapy: A Comparison with ¹⁸F-FDG PET.
Elvas F, Boddaert J, Vangestel C, Pak K, Gray B, Kumar-Singh S, Staelens S, Stroobants S, Wyffels L. J Nucl Med. 2017 Apr;58(4):665-670. doi: 10.2967/jnumed.116.182014. Epub 2016 Nov 22. PMID: 27879368 Free article.

Early Prediction of Tumor Response to Treatment: Preclinical Validation of 99mTc-Duramycin.
Elvas F, Vangestel C, Pak K, Vermeulen P, Gray B, Stroobants S, Staelens S, Wyffels L. J Nucl Med. 2016 May;57(5):805-11. doi: 10.2967/jnumed.115.168344. Epub 2016 Feb 2. PMID: 26837335 Free article.

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